Major Employers
| Employers | Number of Employees | Union |
| Continental Electronics |
1,500 | No |
| Seguin Independent School District School District |
1,259 | No |
| CMC Steel Texas Steel Products |
840 | No |
| Guadalupe Regional Medical Center Health Care |
867 | No |
| Tyson Foods Poultry Processing |
650 | No |
| Wal-Mart Supercenter Retail |
408 | No |
| Guadalupe County Government |
471 | No |
| Alamo Industrial Roadside Maintenance Equipment |
192 | No |
| City of Seguin Government |
330 | No |
| Texas Lutheran University Higher Education |
300 | No |
| Hexcel Schwebel Composite Fabrics |
205 | No |
| H-E-B Food Store Retail Grocery |
220 | No |
